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Fragrance material review on linalool.

C S Letizia1, J Cocchiara, J Lalko

  • 1Research Institute for Fragrance Materials, Inc. 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. letizia@rifm.org

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 14, 2003
PubMed
Summary

This review examines the toxicologic and dermatologic safety of linalool, a common fragrance ingredient. It provides a comprehensive overview of potential risks associated with its use.

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Area of Science:

  • Toxicology
  • Dermatology
  • Fragrance Chemistry

Background:

  • Linalool is widely utilized as a fragrance ingredient in various consumer products.
  • Understanding its toxicologic and dermatologic profile is crucial for consumer safety.
  • Previous research has indicated potential for skin sensitization.

Purpose of the Study:

  • To conduct a comprehensive toxicologic and dermatologic review of linalool.
  • To evaluate the safety of linalool when used as a fragrance ingredient.
  • To consolidate existing data on linalool's potential adverse effects.

Main Methods:

  • Literature review of toxicologic and dermatologic studies.
  • Analysis of safety data from regulatory bodies and scientific publications.

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  • Assessment of linalool's properties and exposure routes.

    • Main Results:

    • Linalool exhibits a low order of acute toxicity.
    • Dermal exposure is the primary route of concern for potential adverse effects.
    • Evidence suggests a potential for skin sensitization in susceptible individuals.

    Conclusions:

    • Linalool is generally considered safe for use as a fragrance ingredient at typical concentrations.
    • Further research may be warranted to fully elucidate sensitization potential.
    • Risk assessment should consider concentration and product type.