Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemokines and diseases.

Victor M Dong1, David H McDermott, Reza Abdi

  • 1Clinical Operations and Medical Affairs, Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062, USA.

European Journal of Dermatology : EJD
|June 14, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic Genetic Rescue of Immunodeficiency in WHIM Syndrome.

The New England journal of medicine·2026
Same author

Heterogeneous evolution of pancreatic cancer microvasculature revealed by longitudinal intravital imaging.

Cancer cell international·2026
Same author

Permissive skin microbiomes in WHIM syndrome: HPV and pathogen expansion.

The Journal of investigative dermatology·2026
Same author

Xenotransplantation: lessons from history, genetic engineering, and early clinical experience-an interview with Dr. David K. C. Cooper.

Frontiers in transplantation·2026
Same author

CXCR4 coordinates adhesion, migration, and development of human NK cells.

bioRxiv : the preprint server for biology·2026
Same author

Continuous Infusion of the CXCR4 Antagonist Plerixafor for WHIM Syndrome.

Journal of clinical immunology·2026

Chemokines, small inflammatory molecules, are crucial for immune cell movement and function. Their dysregulation links to diseases like HIV, cancer, and autoimmune disorders.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathophysiology

Background:

  • Chemokines are small, pro-inflammatory signaling molecules.
  • Initially recognized for leukocyte recruitment to inflammation sites.
  • Now understood as key regulators of immune cell development and distribution.

Purpose of the Study:

  • To review the physiology of chemokines.
  • To highlight their roles in immune cell orchestration.
  • To discuss their involvement in major disease pathogenesis.

Main Methods:

  • Literature review of chemokine function and disease association.
  • Synthesis of current understanding of chemokine physiology.
  • Analysis of chemokines' roles in innate and adaptive immunity.

Related Experiment Videos

Main Results:

  • Chemokines direct leukocyte subsets to inflammatory sites and regulate their activation.
  • They are critical for immune cell development, differentiation, and distribution.
  • Chemokines coordinate dendritic cells and lymphocytes, influencing innate and adaptive immunity.

Conclusions:

  • Chemokines are central to immune responses and homeostasis.
  • Dysregulation of chemokine pathways is implicated in diverse diseases.
  • Understanding chemokines offers therapeutic targets for inflammatory and immune-related conditions.