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Updated: Jul 31, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024
[Acute myeloblastic leukemia without maturation (AML-M1) with basophilic elements and associated with translocation
S Dimicoli1, A Fohlen-Walter, L Mansuy
1Hématologie biologique, CHU de Nancy, 54511 Vandoeuvre-Les-Nancy.
Abstract:
The clinical, hematological, and cytogenetic data from a 4 year-old child with acute myeloid (AML-M1) and basophilia is reported. Interestingly, cytogenetic investigations revealed the presence of the translocation t(6;9) (p23;q34). This abnormality is rare and associated with myelodysplastic syndromes or with subtypes of acute myeloid leukemia (M1, M2, M4, M7), usually with preceding or underlying myelodysplasia. The prognosis is poor, without response to chemotherapy regimen alone. Allogeneic bone marrow transplantation appears likely to be a more appropriate treatment.
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