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Related Experiment Videos

Why homeodynamics, not homeostasis?

D Lloyd1, M A Aon, S Cortassa

  • 1Microbiology (BIOSI), Cardiff University, P.O. Box 915, Cardiff, CF10 3TL, Wales, UK. LloydD@Cardiff.ac.uk

Thescientificworldjournal
|June 14, 2003
PubMed
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Biological systems exhibit dynamic self-organization, termed homeodynamics, moving beyond classical homeostasis. This concept explains complex behaviors like switches and waves, crucial for life's organized complexity.

Area of Science:

  • Biophysics
  • Systems Biology
  • Theoretical Biology

Background:

  • Homeostasis, the idea of maintaining a stable internal environment, has historical roots dating back to ancient Greek philosophy.
  • Key figures like Cannon and von Bertalanffy advanced the mechanistic understanding of biological component turnover.
  • Self-organization and Dynamic Systems Theory provided frameworks for analyzing the complexity of living systems.

Purpose of the Study:

  • To introduce the concept of homeodynamics as a more comprehensive framework for understanding biological systems.
  • To challenge the classical homeostatic view by highlighting dynamic self-organization and instability.
  • To explain the diverse behaviors observed in living systems beyond simple steady states.

Main Methods:

  • Historical analysis of concepts related to biological system stability.

Related Experiment Videos

  • Application of biophysical theories, including self-organization and Dynamic Systems Theory.
  • Integration of theoretical frameworks with experimental observations of cellular phenomena.

    • Main Results:

    • Classical homeostasis, focused on stability, is only one operational mode and potentially an exception.
    • Biological systems are homeodynamic, characterized by dynamic self-organization at points of instability (bifurcations).
    • Homeodynamics explains emergent behaviors such as bistability, thresholds, waves, and chaotic dynamics across various scales.

    Conclusions:

    • Homeodynamics offers a new paradigm, emphasizing dynamic self-organization over static stability.
    • Living systems exhibit complex, emergent behaviors due to their homeodynamic nature.
    • Dynamic organization under homeodynamic conditions is fundamental to the organized complexity of life.