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Related Experiment Videos

Cold-induced metabolism.

Wouter D van Marken Lichtenbelt1, Hein A M Daanen

  • 1Department of Human Biology, Maastricht University, Maastricht, The Netherlands.

Current Opinion in Clinical Nutrition and Metabolic Care
|June 14, 2003
PubMed
Summary
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Individual differences in nonshivering thermogenesis (NST) affect cold response and obesity risk in adults. Further research on environmental and genetic factors influencing NST is needed for potential therapeutic strategies.

Area of Science:

  • Human physiology
  • Metabolic research
  • Thermogenesis

Background:

  • Cold response involves insulative and metabolic processes.
  • Nonshivering thermogenesis (NST) is key in infants and animals, but its role in adults is less understood.
  • This review focuses on recent findings regarding NST in adult humans.

Purpose of the Study:

  • To explore the role and variability of nonshivering thermogenesis in adult humans.
  • To present recent findings on mechanisms underlying NST.
  • To discuss factors influencing individual differences in cold response.

Main Methods:

  • Review of recent studies on nonshivering thermogenesis in humans.
  • Emphasis on uncoupling proteins, mitochondrial ATP-synthase, and calcium cycling.

Related Experiment Videos

  • Discussion of skeletal muscle's contribution to NST.

    • Main Results:

    • Significant individual variation exists in mild cold response, differing in insulative versus metabolic contributions.
    • Factors like age, gender, fitness, adaptation, diet, and genetics influence NST.
    • Potential mechanisms include uncoupling proteins, mitochondrial ATP-synthase, and calcium cycling.

    Conclusions:

    • Low metabolic response to cold may increase obesity risk.
    • More controlled studies are needed on environmental and genetic influences on NST.
    • Future research may enable pharmacological interventions mimicking cold adaptation.