Outcome of coma in children
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Updated: Sep 25, 2026

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion
Published on: July 5, 2024
Hubert K Trübel1, Edward Novotny, George Lister
1Department of Pediatrics, Yale University Medical School, New Haven, Connecticut 06520, USA.
Insights
Predicting outcomes for children in a coma after hypoxic-ischemic events is crucial. This review examines factors like physical findings and lab tests to help clinicians determine prognosis early.
Area of Science:
- Pediatric critical care medicine
- Neurology
- Clinical outcomes research
Background:
- Coma following hypoxic-ischemic events is a critical pediatric condition.
- High mortality and morbidity rates necessitate early prognosis strategies.
- Limited research exists on pediatric coma outcome prediction compared to adults.
Purpose of the Study:
- To review factors predicting outcome in pediatric non-traumatic coma.
- To guide clinicians in early prognostic assessment.
- To explore current and emerging prognostic tools.
Main Methods:
- Literature review of studies on pediatric coma.
- Analysis of factors influencing outcomes in non-traumatic coma.
- Discussion of physical findings, laboratory tools, and newer techniques.
Main Results:
- Key physical findings and accessible laboratory results correlate with pediatric coma outcomes.
- Established prognostic factors from adult studies may apply to children.
- Emerging technologies show potential for improved prognostic accuracy.
Conclusions:
- Accurate prognosis in pediatric coma is essential for guiding treatment and family counseling.
- A combination of clinical assessment and diagnostic tools aids in predicting outcomes.
- Further research into novel techniques is warranted for enhanced prognostic capabilities.
Abstract:
Coma following a hypoxic-ischemic event is a serious condition and common reason for admission to the pediatric intensive care unit. Because coma has a high rate of mortality and morbidity in children, and the clinician may be unsure of the outcome very early in the course, it is important to have strategies to define prognosis. Although most studies have been conducted in adults, we review factors predicting outcome from coma of nontraumatic causes in infants and children. We consider the relation between physical findings, commonly accessible laboratory tools, and outcome, and comment on some newer techniques that may become more available for clinical purposes.
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