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[Yellow Fever].

Pedro Fernando da Costa Vasconcelos1

  • 1Centro Colaborador da Organização Mundial de Saúde para Arbovírus, Instituto Evandro Chagas, Fundação Nacional de Saúde, Ministério da Saúde, Belém, PA, Brasil. pedrovaconcelos@iec.pa.gov.br

Revista Da Sociedade Brasileira De Medicina Tropical
|June 14, 2003
PubMed
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Yellow fever, a viral disease transmitted by mosquitoes, causes mild or severe illness. While preventable with the 17D vaccine, this paper updates information on yellow fever and its vaccine

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Context:

  • Yellow fever is an arboviral disease transmitted by mosquitoes, primarily affecting Africa and South America.
  • The disease cycles between primates and mosquitoes, with varying infection severity and a significant case-fatality rate in severe cases.
  • Urban epidemics still occur in Africa, and South America has reported thousands of cases historically.

Purpose:

  • To provide an updated overview of yellow fever, including its transmission, clinical presentation, and diagnosis.
  • To discuss the epidemiology of yellow fever in endemic regions.
  • To review the 17D vaccine as a preventive measure and address its rare fatal adverse effects.

Summary:

  • Yellow fever is caused by an arbovirus, with jungle cycles involving primates and mosquitoes.

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  • Diagnosis involves serology, virus isolation, immunohistochemistry, and RT-PCR.
  • The 17D vaccine offers protection for at least 10 years, with revaccination recommended thereafter.

    • Impact:

    • Enhances understanding of yellow fever's epidemiology and prevention strategies.
    • Provides crucial information for public health officials and healthcare providers in endemic and at-risk areas.
    • Contributes to the ongoing efforts to control and prevent yellow fever outbreaks through vaccination and surveillance.