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Published on: January 17, 2018
[Meningioma with rhabdoid transformation: case report]
Leodante Batista da Costa1, Josaphat Vilela de Morais
1Fundação Benjamin Guimarães, Belo Horizonte MG, Brasil. leodante@terra.com.br
Abstract:
Meningiomas represent aproximatelly 30% of all intracranial tumors in autopsy studies. With an incidence of 2.3 per 100000, they are considered commom tumors in clinical practice. Twenty percent of the all intracranial tumors diagnosed in vivo are meningiomas. Most of these lesions are benign and the prognosis is intimatelly related to acessibility and ressectability of the lesion. Malignant meningiomas are rare lesions, representing between 1 to 11% of all meningiomas, varying with the definition of pathological criteria for malignancy used, and are categorized in atypical or malignant. Only recently rhabdoid transformation of meningiomas have been reported. We present a case of an extremelly aggressive rhabdoid meningioma in a 56 year-old woman. The tumor was surgically removed twice, with a lethal outcome due to local recurrence, despite maximum radiation and quimiotherapy, six months after the initial presentation.
Insights
Meningiomas are common brain tumors. This case highlights an extremely aggressive rhabdoid meningioma with a fatal recurrence despite aggressive treatment, emphasizing the need for better therapeutic strategies.
Area of Science:
- Neuro-oncology
- Pathology
Background:
- Meningiomas are common intracranial tumors, accounting for approximately 30% of autopsy findings and 20% of in vivo diagnoses.
- Most meningiomas are benign, with prognosis linked to surgical accessibility and resectability.
- Malignant meningiomas, including atypical and malignant types, are rare (1-11%), with rhabdoid transformation being a recently described entity.
Observation:
- A case of an extremely aggressive rhabdoid meningioma in a 56-year-old woman is presented.
- The tumor exhibited rapid local recurrence following two surgical removals.
Findings:
- Despite maximal radiation and chemotherapy, the patient experienced a lethal outcome due to local recurrence six months post-initial presentation.
- The aggressive nature of this rhabdoid meningioma presented significant therapeutic challenges.
Implications:
- This case underscores the aggressive potential of rhabdoid meningiomas.
- Further research into the pathogenesis and treatment of aggressive meningioma subtypes, particularly those with rhabdoid features, is warranted.
- Improved diagnostic and therapeutic strategies are needed for rare, aggressive meningiomas to enhance patient outcomes.
