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CD43 expression in B cell lymphoma.

J Treasure1, A Lane, D B Jones

  • 1University Department of Pathology, Southampton General Hospital.

Journal of Clinical Pathology
|November 1, 1992
PubMed
Summary
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CD43 expression was studied in B cell lymphomas. CD43 is frequently expressed in lymphocytic and centrocytic lymphomas but not in most follicle centre cell lymphomas, aiding in their diagnosis.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • CD43 is a transmembrane glycoprotein expressed on various hematopoietic cells.
  • Its expression patterns in B cell lymphomas can aid in differential diagnosis.

Purpose of the Study:

  • To investigate the expression of CD43 in a diverse cohort of B cell lymphomas.
  • To validate a new CD43 antibody (WR14) for diagnostic use.

Main Methods:

  • Immunohistochemistry was performed on 131 B cell lymphoma samples.
  • Epitope blocking studies validated the WR14 antibody against the established MT1 antibody.
  • Expression of CD43 was correlated with CD5 expression.

Main Results:

  • The WR14 antibody was confirmed as a reliable CD43 reagent.

Related Experiment Videos

  • CD43 was expressed in 84% of lymphocytic lymphomas and 78% of centrocytic lymphomas.
  • 91% of follicle centre cell lymphomas (FCC) were negative for CD43.
  • CD43 expression was significantly associated with CD5 expression (p < 0.001).

    • Conclusions:

    • CD43 expression differs significantly between FCC and non-FCC lymphomas.
    • CD43 and CD5 antibodies can be used together for immunophenotypic discrimination of B cell lymphomas.