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Gabapentin in geriatric mania.

M Awais Sethi1, Raghunath Mehta, D P Devanand

  • 1Columbia University-Binghamton Psychiatric Center geriatric psychiatry fellowship program, Arden Hill Hospital, and Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia Univ., NY, USA.

Journal of Geriatric Psychiatry and Neurology
|June 17, 2003
PubMed
Summary
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Gabapentin effectively treated mania in elderly patients with minimal side effects. This suggests gabapentin may be a safe adjunctive treatment for geriatric mania.

Area of Science:

  • Geriatric Psychiatry
  • Pharmacology

Background:

  • Limited data exists on anticonvulsant use for mania in elderly individuals.
  • Geriatric mania presents unique treatment challenges.

Observation:

  • Seven elderly patients experiencing manic episodes were treated with gabapentin.
  • Gabapentin was administered as an add-on therapy to antipsychotics or valproate.

Findings:

  • All seven patients showed improvement in manic symptoms.
  • Gabapentin was well-tolerated, with minimal to no adverse side effects or drug interactions observed.
  • The treatment was effective when gabapentin was combined with antipsychotic medications or valproate.

Implications:

  • Gabapentin shows promise as a safe and effective adjunctive treatment for geriatric mania.

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  • Further controlled studies are recommended to confirm efficacy and assess side effect profiles of gabapentin in this population.