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Parametrial spread is a prognostic factor in endometrial carcinoma
1Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan.
European Journal of Gynaecological Oncology
|June 17, 2003
Summary
Parametrial spread in endometrial carcinoma is not well understood but is linked to poor prognosis. This study found parametrial involvement in 5.9% of patients, correlating with advanced disease and recurrence.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
- Cancer Prognostics
Background:
- Parametrial spread in endometrial carcinoma is poorly understood.
- Its prognostic significance and correlation with other factors require clarification.
Purpose of the Study:
- To investigate the histopathological patterns of parametrial spread in endometrial carcinoma.
- To evaluate the prognostic significance of parametrial spread and its correlation with other clinicopathological factors.
Main Methods:
- Histopathological review of resected parametria from 269 endometrial carcinoma patients.
- Analysis of correlations between parametrial spread and tumor grade, invasion depth, lymphovascular space invasion (LVSI), cervical invasion, metastasis, and cytology.
- Evaluation of clinical outcomes in patients with parametrial spread.
Main Results:
- Parametrial spread was identified in 5.9% of patients (16/269).
- Spread patterns included direct invasion, LVSI, and lymph node metastasis.
- Parametrial involvement significantly correlated with advanced FIGO stage, deep myometrial invasion, cervical invasion, lymph node metastasis, adnexal metastasis, and positive peritoneal cytology.
- Patients with parametrial spread had a high recurrence rate (37.5%) and mortality.
Conclusions:
- Parametrial spread, via direct extension or lymphatic involvement, occurs in endometrial carcinoma.
- Parametrial spread is a significant indicator of poor prognosis in endometrial carcinoma patients.