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Sertraline-induced hypomania: a genuine side-effect.

D N Mendhekar1, D Gupta, V Girotra

  • 1Department of Psychiatry, GB Pant Hospital, New Delhi, India.deegupta_2000@yahoo.com

Acta Psychiatrica Scandinavica
|June 17, 2003
PubMed
Summary

Selective serotonin reuptake inhibitor (SSRI) treatment can induce hypomania. This case report details sertraline-induced hypomania in a patient with dissociative disorder, suggesting it as a genuine side effect.

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Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressants.
  • SSRI-associated mania or hypomania is a documented phenomenon, often observed in patients with pre-existing mood disorders or risk factors for bipolar disorder.

Observation:

  • A case report describes a 23-year-old female patient diagnosed with a dissociative disorder.
  • The patient experienced hypomanic symptoms after initiating sertraline at 50 mg/day.

Findings:

  • Hypomanic symptoms appeared within 3-4 days of sertraline initiation.
  • Symptoms resolved completely within 7 days of discontinuing sertraline.
  • The patient had no identified risk factors for a manic switch, such as a history of mood disorders or bipolar disorder.

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Implications:

  • This case suggests that hypomania can be a genuine side effect of sertraline, even in patients without typical risk factors for bipolar disorder.
  • Highlights the importance of considering drug-induced hypomania in differential diagnosis.
  • Further research may be warranted to understand the mechanisms of SSRI-induced hypomania in diverse patient populations.