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Related Experiment Videos

Tissue factor signal transduction in angiogenesis.

Henri H Versteeg1, Maikel P Peppelenbosch, C Arnold Spek

  • 1Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Carcinogenesis
|June 17, 2003
PubMed
Summary

Tissue factor (TF) regulates cancer growth and blood vessel formation through both coagulation-dependent and independent pathways. This review explores recent evidence on TF

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Tissue factor (TF) is a transmembrane glycoprotein crucial for oncogenic neoangiogenesis.
  • Initially known for its role in coagulation, TF also acts as a cytokine-like receptor.
  • TF's coagulation-independent functions include regulating tumor growth and inflammation.

Purpose of the Study:

  • To review recent evidence on the dual role of Tissue Factor in angiogenesis.
  • To elucidate the molecular mechanisms of TF-mediated signal transduction in cancer.

Main Methods:

  • Literature review of recent scientific evidence.
  • Analysis of molecular mechanisms underlying TF functions.

Main Results:

Related Experiment Videos

  • TF regulates tumor growth and blood vessel formation.
  • TF-mediated signal transduction involves both coagulation-dependent and independent pathways.
  • TF plays a significant role in inflammation and sepsis.

    • Conclusions:

    • TF is a key regulator of cancer progression and angiogenesis.
    • Understanding TF's complex roles is vital for therapeutic strategies.
    • TF's involvement in both coagulation and non-coagulation pathways highlights its multifaceted nature in disease.