Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular changes and damage in mechanically overloaded hearts.

P Y Hatt

    Recent Advances in Studies on Cardiac Structure and Metabolism
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cardiac ultrastructural abnormalities in Syrian hamsters with spontaneous cardiomyopathy or subjected to cardiac overloads.

    Basic research in cardiology·1992
    Same author

    Morphological approach to the mechanism of heart failure.

    Cardiology·1988
    Same author

    Relationship of myocardial morphometry in aortic valve regurgitation to myocardial function and post-operative results.

    Basic research in cardiology·1988
    Same author

    [Influence of preload on myocardial relaxation in the rat].

    Archives des maladies du coeur et des vaisseaux·1987
    Same author

    Relationship between inotropy and relaxation in rat myocardium.

    The American journal of physiology·1986
    Same author

    [Absence of ultra-structural histological lesions of the myocardium in cardiac insufficiency of hyperthyroidism].

    Annales de medecine interne·1986
    Same journal

    Transmural gradients in ischemic canine left ventricle: effects of blood reflow on glycolytic intermediates.

    Recent advances in studies on cardiac structure and metabolism·1976
    Same journal

    The effects of coronary artery ligation on transmural high-energy phosphates following 20 minutes of blood reflow.

    Recent advances in studies on cardiac structure and metabolism·1976
    Same journal

    Subcellular localization of cardiac adenylate cyclase: sarcolemma or sarcoplasmic reticulum?

    Recent advances in studies on cardiac structure and metabolism·1976
    Same journal

    Dual effects of fluoride on the action potential, contraction, and membrane currents in frog atrial muscle.

    Recent advances in studies on cardiac structure and metabolism·1976
    Same journal

    Membrane calcium current in cardiac excitation: effects of ATP and related substances and sodium pump on bullfrog atrium.

    Recent advances in studies on cardiac structure and metabolism·1976
    Same journal

    Relaxation of frog myocardium.

    Recent advances in studies on cardiac structure and metabolism·1976
    See all related articles

    Mechanical overload in the heart causes myocardial cell damage, with severity correlating to damage extent. Cellular changes reflect increased protein synthesis and growth, potentially leading to regression to a fetal state in severe cases.

    Area of Science:

    • Cardiovascular Biology
    • Cellular Pathology
    • Electron Microscopy

    Background:

    • Mechanical overload is a significant stressor on the heart.
    • Understanding myocardial cell responses is crucial for treating heart conditions.

    Purpose of the Study:

    • To review electron microscopic findings in mechanically overloaded myocardial cells.
    • To correlate observed cellular alterations with overload severity and duration.

    Main Methods:

    • Electron microscopy of myocardial cells from mechanically overloaded hearts.
    • Analysis of cellular structures including mitochondria, myofibrils, and Golgi apparatus.

    Main Results:

    • Degenerative changes in myocardial cells increase with overload severity, potentially causing interstitial fibrosis.

    Related Experiment Videos

  • Cellular alterations indicate increased protein synthesis and growth of organelles.
  • Severe, long-term overload can induce regression to a fetal-like cellular state.

    • Conclusions:

    • Myocardial cell response to mechanical overload involves both adaptive growth and degenerative processes.
    • The severity and duration of overload dictate the nature and extent of cellular changes.
    • Observed changes suggest a complex interplay between cellular stress, adaptation, and potential dedifferentiation.