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False discovery rate in linkage and association genome screens for complex disorders
Chiara Sabatti1, Susan Service, Nelson Freimer
1Department of Human Genetics and Statistics, University of California, Los Angeles 90095-7088, USA. csabatti@mednet.ucla.edu
Genetics
|June 17, 2003
Abstract:
We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.