Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Design Example01:23

Design Example

The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role" [BBA Mol. Cell Res. 1873 (2026) 120081].

Biochimica et biophysica acta. Molecular cell research·2026
Same author

Automation of high-throughput workflow for arrayed CRISPR activation library screening.

bioRxiv : the preprint server for biology·2025
Same author

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.

Biochimica et biophysica acta. Molecular cell research·2025
Same author

Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum.

Frontiers in neuroanatomy·2025
Same author

Single-cell omics and heterogeneity of neuroglial cells.

Handbook of clinical neurology·2025
Same author

An Astrocyte Transplantation Method to Investigate Astrocyte Development and Diversity in the Central Nervous System (CNS).

Methods in molecular biology (Clifton, N.J.)·2025

Related Experiment Video

Updated: Jul 10, 2026

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
09:43

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

'Eph'ective signaling: forward, reverse and crosstalk.

Keith K Murai1, Elena B Pasquale

  • 1The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA.

Journal of Cell Science
|June 17, 2003
PubMed
Summary

Eph receptors and ephrin ligands regulate cell shape and movement, not proliferation. Understanding their bidirectional signaling pathways is key to basic biology and disease insights.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Eph receptors are the largest receptor tyrosine kinase family.
  • Ephrins are their membrane-bound ligands, located in lipid rafts.
  • These proteins are crucial in developing and mature tissues.

Purpose of the Study:

  • To summarize the known functions of Eph receptors and ephrin ligands.
  • To highlight their unique role in regulating cell shape and movement.
  • To emphasize the importance of understanding their bidirectional signaling.

Main Methods:

  • Review of existing literature on Eph receptor and ephrin signaling.
  • Analysis of studies investigating cellular processes regulated by Eph-ephrin complexes.
  • Examination of the intricate signaling networks involved.

More Related Videos

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells
14:12

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells

Published on: December 11, 2021

Optogenetic Signaling Activation in Zebrafish Embryos
07:18

Optogenetic Signaling Activation in Zebrafish Embryos

Published on: October 27, 2023

Related Experiment Videos

Last Updated: Jul 10, 2026

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
09:43

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells
14:12

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells

Published on: December 11, 2021

Optogenetic Signaling Activation in Zebrafish Embryos
07:18

Optogenetic Signaling Activation in Zebrafish Embryos

Published on: October 27, 2023

Main Results:

  • Eph receptors and ephrins are implicated in diverse cellular processes.
  • Unlike other receptor tyrosine kinases, Eph signaling primarily affects cell shape and movement.
  • Complex, bidirectional signaling pathways emanate from the Eph receptor-ephrin complex.

Conclusions:

  • Deciphering Eph-ephrin bidirectional pathways is vital for understanding fundamental biological processes.
  • This knowledge can provide significant insights into various diseases.
  • Further research into these signaling networks is warranted.