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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
[Directly observed treatment of latent tuberculosis infection: comparative study of two isoniazid regimens]
Joaquín Portilla1, Pilar Jordá, Javier Esteban
1Unidad de Enfermedades Infecciosas. Hospital General Universitario de Alicante. Spain.
Introduction:
To compare compliance with two isoniazid regimens in drug users with latent tuberculosis infection. METHODS.
Design:
clinical trial. Group 1: isoniazid 300 mg once daily (16 patients); Group 2: isoniazid 900 mg/twice weekly (21).
Endpoints:
compliance, toxicity and efficacy.
Results:
Group 1 vs. Group 2: continuation in program 81/82% (p 5 NS), compliance full doses 43.7/66.6% (p 5 0.1), median percentage of days not taking isoniazid: 1.8 (0.2-4.3) vs. 0 (0-1.7) (p 5 0.06).
Conclusions:
Compliance was high in both therapeutic arms. The twice-weekly isoniazid regimen favored compliance, but differences were not significant.
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