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Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans
Published on: February 27, 2012
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MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing
1Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA. vambros@dartmouth.edu
Cell
|June 18, 2003
Abstract:
Drosophila geneticists have uncovered roles for microRNAs in the coordination of cell proliferation and cell death during development, and in stress resistance and fat metabolism. In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing.
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