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Bone mineral density correlates strongly with basal metabolic rate in postmenopausal women
1Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea. jwchoi@inha.ac.kr
Background:
This study investigated the relationships of bone mineral density (BMD) with body composition, basal metabolic rate (BMR), and fat distribution.
Methods:
We measured body mass index (BMI), anthropometrics, and BMD in 345 postmenopausal women and 224 elderly men. Total body fat (TBF), fat distribution, and BMR were assessed using a body composition analyzer. Lumbar spine and proximal femur BMDs were measured with dual-energy X-ray absorptiometry.
Results:
Lumbar spine BMD was more strongly correlated with BMR (r=0.51, p<0.01) than with lean body mass (r=0.39, p<0.01) and waist hip ratio (r=-0.28, p<0.01) in postmenopausal women. The mean values of BMR in osteoporotic women were significantly lower than those for non-osteoporotic women (p<0.01). The prevalences of osteoporosis at the sites of lumbar spine and proximal femur were 32.1% and 23.3% in the women with BMR<1230 kcal, which were significantly higher than those of osteoporosis (5.4% and 7.7%) at the corresponding sites in the women with BMR> or =1230 kcal (p<0.01). In elderly men, the incidence of osteoporosis at the proximal femur was 29.5% in the subjects with BMR<1390 kcal, significantly higher than that (2.2%) in the subjects with BMR> or =1390 kcal (p<0.01).
Conclusion:
BMR is more closely associated with bone density in elderly persons, at least as compared to TBF, BMI, or lean body mass.