Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk factors for chronic constipation based on a general practice sample.

Nicholas J Talley1, Michael Jones, Guy Nuyts

  • 1Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia.

The American Journal of Gastroenterology
|June 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A three-arm randomised controlled trial comparing ultra-low intensity interventions for gratitude vs. things you do vs. waitlist control for depression and anxiety in health professionals.

Behaviour research and therapy·2026
Same author

A large language model framework for sample-free population synthesis.

PloS one·2026
Same author

Integrating enriched case data from national laboratory testing with population-based case-control analyses: a novel statistical likelihood-ratio methodology for PS4 applied to 325,345 breast cancer cases and 671,006 controls.

medRxiv : the preprint server for health sciences·2026
Same author

Impact of Restriction-Resumption Protocols on Mood and Anxiety in Healthy Adults: Randomized Controlled Trial.

JMIR formative research·2026
Same author

A Clinical Practice Update for the Management of Patients With Disorders of Gut-Brain Interaction and Altered Food Intake Behavior.

Neurogastroenterology and motility·2026
Same author

The role of external quality assessment in detecting immunohistochemical analyses with inferior performance: focus on the anti-ER SP1 clone.

Virchows Archiv : an international journal of pathology·2026
Same journal

Calendar of Courses, Symposiums and Conferences.

The American journal of gastroenterology·2026
Same journal

Molecular Nonendoscopic Tests for the Early Detection of Esophageal Squamous Carcinoma and High-Grade Dysplasia: Promising Progress.

The American journal of gastroenterology·2026
Same journal

ACG Clinical Guideline: Colonic Diverticulitis.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

2026 CME Information.

The American journal of gastroenterology·2026
See all related articles

Medications, particularly antispasmodics and antidepressants, are significant risk factors for constipation. While diseases contribute, drug interactions play a larger role in primary care constipation cases.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Epidemiology

Background:

  • Constipation is a common condition in primary care, with diet and exercise often cited as causes.
  • The influence of medications and underlying medical conditions on constipation risk is less understood.

Purpose of the Study:

  • To identify clinical, therapeutic, and demographic risk factors for constipation in a large patient cohort.
  • To elucidate the specific contributions of various medications to constipation incidence.

Main Methods:

  • Analysis of a large general practice research database spanning over 10 years.
  • Inclusion of patients diagnosed with chronic constipation (n=7251), unspecified constipation (n=6441), and controls (n=7103).

Main Results:

Related Experiment Videos

  • Multiple medications were independently associated with chronic constipation, beyond age and gender.
  • Antispasmodics (OR=3.3), anticonvulsants (OR=2.8), and antidepressants (OR=1.9) showed the highest risks.
  • Neurological diseases were strongly linked but accounted for a small proportion of cases.

Conclusions:

  • Medications are a substantial contributing factor to constipation in primary care settings.
  • Concurrent medical conditions are associated with constipation but contribute to a minority of cases.
  • Further research into medication-induced constipation is warranted.