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Immune responsiveness, tolerance and dsRNA: implications for traditional paradigms
Matthias G von Herrath1, Adrian Bot
1Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Trends in Immunology
|June 18, 2003
Abstract:
Double-stranded (ds)RNA motifs are central to immune regulation and block tolerance to tumor-associated, self- and foreign antigens. In addition, they could explain why DNA vectors encoding self-replicating mRNA (replicons) are more immunogenic than conventional DNA vaccines. Accumulating evidence on the immunomodulatory roles of dsRNAs warrants a reconsideration of various models of immune homeostasis.