Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genes for asthma: much ado about nothing?

Paul A Whittaker1

  • 1Novartis Horsham Respiratory Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. paul.whittaker@pharma.novartis.com

Current Opinion in Pharmacology
|June 18, 2003
PubMed
Summary

Identifying asthma susceptibility genes is challenging due to genetic complexity. Genome-wide screens and gene-gene interaction studies are advancing our understanding of asthma

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of bioinformatics in target validation.

Drug discovery today. Technologies·2014
Same author

Can pharmacology possibly have a role for bioinformatics?

Expert opinion on drug discovery·2013
Same author

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.

American journal of respiratory and critical care medicine·2009
Same author

Oxidative stress modulates theophylline effects on steroid responsiveness.

Biochemical and biophysical research communications·2008
Same author

RNA interference: from gene silencing to gene-specific therapeutics.

Pharmacology & therapeutics·2005
Same author

What is the relevance of bioinformatics to pharmacology?

Trends in pharmacological sciences·2003

Area of Science:

  • Genetics
  • Pulmonology
  • Molecular Biology

Background:

  • Asthma genetics is complex, making susceptibility gene identification difficult.
  • Both academic and industrial research groups are focusing on asthma susceptibility genes.
  • Gene-gene interactions are recognized as important factors in asthma development.

Purpose of the Study:

  • To review the progress in identifying genes associated with asthma susceptibility.
  • To highlight the role of genetic complexity and interactions in asthma.
  • To discuss the implications of genetic discoveries for future asthma therapies.

Main Methods:

  • Genome-wide screens.
  • Positional cloning techniques.
  • Candidate gene studies.

Main Results:

  • Genome-wide screens and positional cloning have begun identifying asthma susceptibility genes.
  • Evidence suggests gene-gene interactions contribute significantly to genetic risk for asthma.
  • Understanding of the genetic basis of asthma has substantially increased.

Conclusions:

  • Continued research into asthma genetics is crucial for understanding molecular pathophysiology.
  • Advances in identifying susceptibility genes will likely lead to novel therapeutic targets for asthma.
  • Future insights from genetic studies promise to improve asthma treatment strategies.

Related Experiment Videos