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Related Experiment Videos

Expandable gastroretentive dosage forms.

Eytan A Klausner1, Eran Lavy, Michael Friedman

  • 1Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem POB 12065, Jerusalem 91120, Israel.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 18, 2003
PubMed
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Expandable gastroretentive dosage forms (GRDFs) prolong drug release in the stomach for enhanced absorption. These systems show promise for treating conditions requiring improved drug delivery and therapeutic efficacy.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Expandable gastroretentive dosage forms (GRDFs) have evolved from veterinary applications to human therapeutics over three decades.
  • These systems are designed to increase gastric retention time (GRT) by expanding in the stomach after oral administration.

Purpose of the Study:

  • To review expandable GRDFs described in scientific literature and patents.
  • To discuss the physiological principles, preclinical models, and clinical potential of these drug delivery systems.

Main Methods:

  • Review of articles and patents focusing on expandable GRDF design and function.
  • Discussion of the physiological basis for gastric retention, including mechanical properties.
  • Inclusion of preclinical (canine model) and clinical study findings, imaging techniques, and PK/PD aspects.

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Main Results:

  • Expandable GRDFs significantly prolong gastric retention time (GRT) through swelling or unfolding mechanisms.
  • The rigidity and size of these forms enhance gastroretentivity against stomach peristalsis.
  • Improved in vivo absorption of drugs with narrow absorption windows has been demonstrated.

Conclusions:

  • Expandable GRDFs offer a viable strategy for improving drug absorption and therapeutic outcomes, particularly for challenging drug compounds.
  • Positive preclinical and clinical results support the advancement of expandable GRDFs towards clinical application.
  • Further research and development are warranted to fully realize the potential of these advanced drug delivery systems.