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Related Experiment Videos

Retinal thickness decreases with age: an OCT study.

B Alamouti1, J Funk

  • 1University of Freiburg Eye Hospital, Germany. alamouti@aug.ukl.uni-freiburg.de

The British Journal of Ophthalmology
|June 19, 2003
PubMed
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Retinal thickness, measured by optical coherence tomography (OCT), decreases with age. While OCT provides reproducible measurements of total retinal thickness, nerve fiber layer measurements are less reproducible. The age-related decrease in retinal thickness has a negligible impact on optic disc reference plane calculations.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Optic Nerve Health

Background:

  • Three-dimensional optic disc tomography requires a reference plane for calculating optic disc rim/cup values.
  • The reference plane's position often depends on temporal disc margin retinal thickness.
  • Previous assumptions suggested temporal disc margin thickness is age-independent.

Purpose of the Study:

  • To test the hypothesis that temporal disc margin retinal thickness is independent of age using optical coherence tomography (OCT).
  • To determine the reproducibility of OCT measurements in the temporal disc margin area.
  • To assess the impact of age-related changes on optic disc reference plane calculations.

Main Methods:

  • 100 healthy volunteers' eyes underwent three OCT scans.

Related Experiment Videos

  • Scans were vertically aligned at the temporal edge of the optic disc.
  • Total retinal thickness and retinal nerve fiber layer (RNFL) thickness were calculated, along with their coefficients of variation (CV).
  • Retinal and RNFL thickness were correlated with participant age.

    • Main Results:

    • Mean total retinal thickness was 249 µm (SD 22 µm) with a CV of 3.5%.
    • Mean RNFL thickness was 109 µm (SD 22 µm) with a CV of 8.0%.
    • Both total retinal thickness (R²=0.133, p=0.0002) and RNFL thickness (R²=0.094, p<0.0019) showed significant negative correlations with age.

    Conclusions:

    • OCT enables highly reproducible total retinal thickness measurements (CV=3.5%).
    • RNFL thickness measurements exhibit lower reproducibility (CV=8.0%).
    • Both retinal and RNFL thickness significantly decrease with age, but this effect on the reference plane is negligible.