Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detecting chloroquine retinopathy: electro-oculogram versus colour vision.

A S Neubauer1, K Samari-Kermani, U Schaller

  • 1Department of Ophthalmology, Ludwig-Maximilians-Universität, Munich, Germany. aneubaue@ak-i.med.uni-muenchen.de

The British Journal of Ophthalmology
|June 19, 2003
PubMed
Summary

Computerised colour vision testing is a sensitive screening tool for antimalarial retinopathy. A normal colour vision test virtually excludes retinopathy, while the electro-oculogram (EOG) has limited diagnostic value.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen.

Scientific reports·2025
Same author

Budget impact of the Oncotype DX® test compared to other gene expression tests in patients with early breast cancer in Germany.

Cancer treatment and research communications·2022
Same author

[Retinal detachment in children and adolescents. Specific clinical features].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2019
Same author

Effects of three husbandry systems on health, welfare and productivity of organic pigs.

Animal : an international journal of animal bioscience·2019
Same author

Homozygous XYLT2 variants as a cause of spondyloocular syndrome.

Clinical genetics·2017
Same author

Zeolite-based, dry formulations for conservation and practical application of Paraburkholderia phytofirmans PsJN.

Journal of applied microbiology·2016

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Background:

  • Long-term use of chloroquine and hydroxychloroquine can cause ocular toxicity, specifically retinopathy.
  • Early detection of chloroquine retinopathy is crucial to prevent vision loss.

Purpose of the Study:

  • To compare the sensitivity and specificity of the electro-oculogram (EOG) and a computerised colour vision test for screening chloroquine/hydroxychloroquine retinopathy.
  • To identify the earliest signs of antimalarial-induced ocular toxicity.

Main Methods:

  • 93 patients on long-term chloroquine/hydroxychloroquine therapy were monitored for 2.6 years.
  • Regular clinical examinations, EOG, and quantitative colour vision tests (tritan and protan axes) were performed every six months.

Related Experiment Videos

Main Results:

  • Colour vision testing showed higher sensitivity and specificity than EOG for detecting retinopathy.
  • Disturbances in the tritan axis of colour vision were observed first in patients with early retinopathy.
  • Four patients developed bull's eye maculopathy, all with significant colour vision defects; EOG was not a reliable indicator.

Conclusions:

  • Computerised colour vision testing, particularly assessing the tritan axis, is a valuable and sensitive method for screening antimalarial retinopathy.
  • A normal colour vision test result effectively rules out retinopathy.
  • The EOG is of limited value in diagnosing early or advanced chloroquine retinopathy.