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Related Experiment Videos

Diffusion imaging in obstructive hydrocephalus.

Aziz M Uluğ1, Thuy N Truong, Christopher G Filippi

  • 1Department of Radiology, Weill Medical College of Cornell University, Box 141, 1300 York Avenue, New York, NY 10021, USA.

AJNR. American Journal of Neuroradiology
|June 19, 2003
PubMed
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Diffusion imaging can detect interstitial edema in obstructive hydrocephalus. Increased average diffusion (D(av)) in periventricular white matter may indicate hydrocephalus and help assess treatment response.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Hydrocephalus leads to transependymal cerebrospinal fluid resorption.
  • This process causes periventricular interstitial edema.

Purpose of the Study:

  • To determine if diffusion imaging can detect periventricular interstitial edema in obstructive hydrocephalus.
  • To assess if diffusion imaging can monitor treatment response.

Main Methods:

  • MR diffusion imaging was used in 21 obstructive hydrocephalus patients before and after treatment.
  • Ventricular size was measured using the frontal and occipital horn ratio.
  • Periventricular white matter signal intensity and average diffusion constants (D(av)) were analyzed.

Main Results:

Related Experiment Videos

  • Average diffusion (D(av)) in periventricular white matter was 6.9% higher in hydrocephalic patients versus controls.
  • After treatment, D(av) decreased by 6.0%, with 53% of patients showing a decrease.

Conclusions:

  • Increased D(av) in periventricular white matter is a potential imaging biomarker for obstructive hydrocephalus.
  • D(av) measurement may aid in diagnosing equivocal cases and monitoring treatment efficacy.