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Updated: Jun 23, 2026

Barnes Maze Testing Strategies with Small and Large Rodent Models
Published on: February 27, 2014
Tolerance: of mice and men
1Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. sachs@helix.mgh.harvard.edu
Little is known about the effect of an individual's immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.
Little is known about the effect of an individual's immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.
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