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[Metal poisoning].

A Ferrer1

  • 1Unidad de Toxicología Clínica, Hospital Clínico Universitario, San Juan Bosco 15, 50009 Zaragoza, Spain. Itox-unidad@hcu-lblesa.es

Anales Del Sistema Sanitario De Navarra
|June 19, 2003
PubMed
Summary
This summary is machine-generated.

This study reviews metal toxicity, detailing how compounds affect the body and lead to multisystemic diseases. It highlights chelating agents like British Anti-Lewisite (BAL) as key treatments for metal poisoning.

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Area of Science:

  • Environmental Toxicology
  • Metallomics
  • Biochemistry

Context:

  • Ubiquitous exposure to metals from industrialization, work, and environmental pollution.
  • Metal toxicity is element-specific but influenced by compound type, solubility, and toxicokinetics.
  • Biomolecular targets include enzymatic proteins, leading to multisystemic pathologies.

Purpose:

  • To review the toxicokinetics, mechanisms, clinical presentations, and treatments of toxic metals.
  • To discuss the role of chelating agents in metal detoxification.
  • To focus on lead, mercury, and arsenic as significant toxic metalloids.

Summary:

  • Metal toxicity affects multiple organ systems, including gastrointestinal, neurological, hematological, and renal systems.
  • Enzymatic proteins are primary biomolecular targets, contributing to diverse pathologies.

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  • Chelating agents like BAL, DMPS, DMSA, EDTA, Penicillamine, and Deferoxamine are crucial for treatment by forming non-toxic excretable complexes.

    • Impact:

    • Provides a comprehensive overview of metal toxicity and management strategies.
    • Emphasizes the importance of understanding toxicokinetics for effective treatment.
    • Informs clinical practice and public health regarding metal-induced diseases and their remediation.