[The dynamics of the quantitative changes in neurospecific proteins in the blood of neural cancer patients]

The authors studied the effect of a neurosurgical intervention on the dynamics of quantitative changes of neurospecific proteins (NSP(--alpha 1 and alpha 2 globulins of the brain (alpha GM1, alpha GM2), L2 glycoprotein (alpha GP2), and glyofibril acid protein (GFA)--in blood of neuro-oncological patients. High background NSP values were revealed in most of the 14 examined patients for the first time. A significant increase of the amount of proteins in the blood during anesthesia and in the course or the operation was found. Deviation of values from the average statistical parameters was encountered in patients with an unfavorable outcome. The results of the study point to marked changes of the blood-brain barrier in neuro-oncological patients.