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The epidermal growth factor precursor in the rat kidney seems to be processed by an aprotinin sensitive proteinase
P E Jørgensen1, E Nexø, S S Poulsen
1Department B, University of Copenhagen, Denmark.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
Epidermal growth factor (EGF) is synthesized as a membrane bound precursor in the rat kidney. The precursor seems to be processed by an aprotinin sensitive proteinase. Intravenous infusion of aprotinin reduces the urinary excretion of EGF by 85% and increases the amount of renal EGF. Kidney membranes incubated at 37 degrees C release EGF and this release is inhibited by aprotinin.