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Updated: Aug 16, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
[Interleukin 1 signal transduction]
Yasuhiro Yoshida1, Uki Yamashita
1Department of Immunology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Abstract:
In the human body, several factors play immunological roles. The molecular mechanisms of functions of these factors have been investigated extensively in the past. Interleukin 1 (IL-1) is a secreted protein and performs a central part in inflammatory responses. IL-1 binds to cell surface specific receptors and activates transcription factors through cytoplasmic mediators such as Myeloid differentiation factor 88 (MyD88), IL-1 receptor-associated kinase (IRAK) and TNF receptor-associated factor 6 (TRAF6). These are responsible for the induction of target genes, which are able to orchestrate or suppress the immune response. This review summarizes the available information to date on the signal transduction of IL-1.
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