Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interleukin 1 signal transduction].

Yasuhiro Yoshida1, Uki Yamashita

  • 1Department of Immunology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Journal of UOEH
|June 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commuter-related ocular symptoms and eyewash intervention in an urban setting: a non-randomized interventional study in Bandung, Indonesia. The first report of the Bandung eyewash study.

Environmental science and pollution research international·2026
Same author

Global association between ambient air pollution and age-related macular degeneration: an ecological analysis across 203 countries.

Environmental science and pollution research international·2026
Same author

Highly alkaline mineral trioxide aggregate (MTA) affects restorative materials.

Dental materials : official publication of the Academy of Dental Materials·2026
Same author

Novel chemical initiator using borate salt and sulfonic acid group-containing copolymer for an MMA-based adhesive resin cement.

Dental materials : official publication of the Academy of Dental Materials·2026
Same author

Beyond Exposure Levels: Oxidative Stress as a Unifying Axis Linking Particulate Matter, Light, and Protective Interventions.

Antioxidants (Basel, Switzerland)·2026
Same author

Effect of Surface Morphology Formed by Additive Manufacturing on the Adhesion of Dental Cements to Zirconia.

Materials (Basel, Switzerland)·2026
Same journal

Navigating Emergency Management: Perspective From Gen-Z Using Modified Disaster Preparedness Evaluation Tools.

Journal of UOEH·2026
Same journal

Exploring the Impact of Sleep Quality on Periodontal Health among Night Shift Factory Workers in Ahmedabad City.

Journal of UOEH·2026
Same journal

Evaluating Ergonomic Risks in Manual Lychee Harvesting Using PATH and Hierarchical Task Analysis: An Observational Cross-Sectional Study.

Journal of UOEH·2026
Same journal

Major Depression and Brain-Derived Neurotrophic Factor.

Journal of UOEH·2026
Same journal

Isolated Fallopian Tube Torsion in a 16-Year-Old Adolescent: A Diagnostic Challenge Mimicking a Functional Ovarian Cyst.

Journal of UOEH·2026
Same journal

Effect of Light-Intensity Physical Activity in An Older-Adult Patient With Minimal Change Nephrotic Syndrome and Acute Kidney Injury: A Case Report.

Journal of UOEH·2026
See all related articles

Interleukin 1 (IL-1) is a key protein in inflammation. This review details how IL-1 signals through specific receptors and mediators like MyD88, IRAK, and TRAF6 to control immune responses.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Context:

  • Interleukin 1 (IL-1) is a crucial secreted protein involved in the human immune system.
  • Understanding IL-1's molecular functions is vital for comprehending inflammatory processes.
  • Extensive research has explored the immunological roles of various factors in the body.

Purpose:

  • To review and summarize the current knowledge on Interleukin 1 (IL-1) signal transduction pathways.
  • To elucidate the molecular mechanisms by which IL-1 influences immune responses.

Summary:

  • IL-1 initiates inflammatory responses by binding to specific cell surface receptors.
  • This binding activates cytoplasmic mediators, including Myeloid differentiation factor 88 (MyD88), IL-1 receptor-associated kinase (IRAK), and TNF receptor-associated factor 6 (TRAF6).

Related Experiment Videos

  • These signaling molecules subsequently activate transcription factors, leading to the induction of target genes that modulate immune responses.

    • Impact:

    • Provides a comprehensive overview of IL-1 signaling, aiding researchers in the field of immunology.
    • Highlights the central role of IL-1 in orchestrating immune responses, offering insights into inflammatory diseases.
    • Serves as a foundational resource for further investigation into IL-1-mediated pathways and therapeutic targets.