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Related Experiment Videos

Precocious pathfinding: retinal axons can navigate in an axonless brain.

E Cornel1, C Holt

  • 1Department of Biology, University of California, San Diego, La Jolla 92093-0322.

Neuron
|December 1, 1992
PubMed
Summary

Retinal ganglion cell axons can find their way without existing nerve tracts. This suggests that cues within the brain

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Axon Guidance

Background:

  • Developing retinal ganglion cell axons navigate the diencephalon to the optic tectum.
  • The tract of the postoptic commissure (TPOC) is an early central nervous system scaffold thought to guide optic axons.

Purpose of the Study:

  • To investigate the role of the TPOC in guiding optic axons.
  • To determine if optic axons can navigate in the absence of preexisting scaffold tracts.

Main Methods:

  • Used heterochronic and xenoplastic transplants of eye primordia in Xenopus.
  • Forced optic axons to enter the brain before the formation of scaffold tracts.

Main Results:

  • Optic axons successfully navigated to the optic tectum without the TPOC.
  • Axonal pathfinding occurred even in the absence of any other axons.

Conclusions:

  • The tract of the postoptic commissure is not essential for optic axon guidance.
  • Axonless neuroepithelial sheets contain sufficient cues for axonal pathfinding.
  • Molecular heterogeneities in the neuroepithelium guide both early and late developing axons.

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