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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure

C Zoccali1, F A Benedetto, F Mallamaci

  • 1Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, c/o Ospedali Riuniti Bianchi-Melacrino-Morelli Via Vallone Petrara, 89124 Reggio Calabria, Italy. carmine.zoccali@tin.it

European Journal of Clinical Investigation
|June 20, 2003
PubMed

Insights

Elevated fibrinogen is linked to adverse cardiac changes in end-stage renal disease (ESRD) patients. Higher fibrinogen levels correlate with left ventricular concentric hypertrophy and impaired systolic function, impacting prognosis.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Biochemistry

Background:

  • Investigated the association between fibrinogen levels and cardiac structure/function in end-stage renal disease (ESRD).
  • Included 192 ESRD patients undergoing echocardiography.

Purpose of the Study:

  • To determine the relationship between fibrinogen and left ventricular (LV) geometry and function in ESRD patients.
  • To assess if fibrinogen is an independent predictor of cardiac abnormalities in this population.

Main Methods:

  • Echocardiographic measurements of LV geometry (e.g., wall thickness, mass index) and function (ejection fraction) were analyzed.
  • Patients were stratified into tertiles based on plasma fibrinogen levels.
  • Multivariate analyses and logistic regression were used to assess independent correlations and risks.

Main Results:

  • Patients in the highest fibrinogen tertile exhibited increased LV mass, wall thickness, and concentric hypertrophy.
  • Higher fibrinogen tertiles were associated with reduced LV end-diastolic diameter and lower LV ejection fraction.
  • Elevated fibrinogen independently predicted LV concentric hypertrophy and was a key factor in LV ejection fraction variance.

Conclusions:

  • Elevated fibrinogen is independently associated with left ventricular concentric hypertrophy and systolic dysfunction in ESRD.
  • These findings suggest that fibrinogen may contribute to the poor prognosis observed in ESRD patients.
  • Fibrinogen may represent a modifiable risk factor for cardiovascular complications in ESRD.
Abstract

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