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Updated: Sep 25, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
Published on: June 25, 2013
Comparison of the properties of prostaglandin H synthase-1 and -2
Richard J Kulmacz1, Wilfred A van der Donk, Ah-Lim Tsai
1Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. richard.j.kulmacz@uth.tmc.edu
Abstract:
Biosynthesis of prostanoid lipid signaling agents from arachidonic acid begins with prostaglandin H synthase (PGHS), a hemoprotein in the myeloperoxidase family. Vertebrates from humans to fish have two principal isoforms of PGHS, termed PGHS-1 and-2. These two isoforms are structurally quite similar, but they have very different pathophysiological roles and are regulated very differently at the level of catalysis. The focus of this review is on the structural and biochemical distinctions between PGHS-1 and-2, and how these differences relate to the functional divergence between the two isoforms.
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