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Related Concept Videos

Dimensions of Health and Illness01:21

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Angina I: Introduction

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Related Experiment Video

Updated: Jul 9, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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Published on: January 7, 2014

von Hippel-Lindau disease.

Russell R Lonser1, Gladys M Glenn, McClellan Walther

  • 1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1414, USA. lonserr@ninds.nih.gov

Lancet (London, England)
|June 20, 2003
PubMed
Summary

Von Hippel-Lindau disease is a rare, inherited cancer syndrome caused by a VHL gene mutation. It increases the risk of various tumors, requiring multidisciplinary management for affected individuals.

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Area of Science:

  • Genetics
  • Oncology
  • Hereditary Cancer Syndromes

Background:

  • Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder.
  • It stems from germline mutations in the VHL tumor suppressor gene on chromosome 3p.
  • VHL disease affects multiple organ systems, increasing cancer risk.

Purpose of the Study:

  • To provide a comprehensive overview of von Hippel-Lindau disease.
  • To detail the clinical manifestations and management strategies.
  • To outline current treatment options for VHL-associated tumors.

Main Methods:

  • Literature review of clinical aspects, management, and treatment.
  • Synthesis of information on VHL disease epidemiology and genetics.
  • Overview of diagnostic criteria and surveillance protocols.

Main Results:

  • VHL disease affects approximately 1 in 36,000 livebirths.
  • Individuals are predisposed to benign and malignant tumors in the CNS, kidneys, adrenals, pancreas, and reproductive organs.
  • Management necessitates a multidisciplinary approach due to tumor diversity.

Conclusions:

  • Von Hippel-Lindau disease is a significant hereditary cancer syndrome.
  • Early diagnosis and multidisciplinary care are crucial for managing VHL disease.
  • Ongoing research aims to improve treatment outcomes for VHL-associated neoplasms.