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Related Experiment Videos

A micromachined silicon multielectrode for multiunit recording.

A J Spence1, R R Hoy, M S Isaacson

  • 1School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA. ajs54@cornell.edu

Journal of Neuroscience Methods
|June 20, 2003
PubMed
Summary
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This study introduces a novel 16-channel multielectrode for recording neural activity in cricket nerve cords. The microfabricated device, using deep reactive ion etching, enables precise neural recordings and analysis of action potentials.

Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Recording propagating action potentials from multiple neurons is crucial for understanding neural circuits.
  • Existing extracellular electrode arrays face limitations in spike resolution and anatomical correlation.
  • Microfabrication techniques offer potential for improved neural recording devices.

Purpose of the Study:

  • To develop and evaluate a novel 16-channel multielectrode for recording from the cricket ventral nerve cord.
  • To assess the fabrication process using deep reactive ion etching (DRIE) for creating rigid, high-density electrode structures.
  • To analyze neural activity, including action potential conduction velocities, using the developed multielectrode.

Main Methods:

  • Fabrication of a 16-channel multielectrode using photolithography and deep reactive ion etching (DRIE).

Related Experiment Videos

  • Recording of propagating action potentials from the ventral nerve cord of Gryllus bimaculatus.
  • Utilizing principle component analysis and clustering to generate spike templates for eight neurons.
  • Analysis of stimulus-evoked activity and calculation of conduction velocities.

    • Main Results:

    • Successfully recorded propagating action potentials from multiple units in the cricket ventral nerve cord.
    • Generated clean spike templates for eight neurons from a 40-second recording.
    • Determined neural conduction velocities ranging from 2.59+/-0.05 to 4.99+/-0.12 m/s.
    • Demonstrated the capability of the microfabricated device for stable positioning and isolation of recording sites.

    Conclusions:

    • The novel microfabricated multielectrode, utilizing DRIE, enables high-density, precise neural recordings.
    • This technology addresses limitations of current extracellular arrays, improving spike resolution and anatomical correlation.
    • The rigid, stable electrode design is suitable for various nerve cord applications, including clamping and squeezing.