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Flow cytometry and its application in small animal oncology
1Clinic of Small Animals, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany. katja.Cculmsee@tiho-hannover.de
Flow cytometry is increasingly used in veterinary oncology for DNA analysis and immunophenotyping of tumors and blood cancers in pets. These methods offer valuable prognostic information for canine cancers.
Area of Science:
- Veterinary Medicine
- Oncology
- Immunology
Background:
- Flow cytometry use in veterinary clinical labs has grown significantly.
- Common applications include DNA content analysis and immunophenotyping of canine cancers.
Purpose of the Study:
- To review the applications of flow cytometry in small animal oncology.
- To discuss the clinical relevance of DNA analysis and immunophenotyping in veterinary cancer patients.
Main Methods:
- Review of existing literature on flow cytometry in small animal oncology.
- Discussion of basic principles, technical aspects, and clinical relevance.
Main Results:
- DNA ploidy and S-phase rate in canine tumors are independent predictors of patient outcome.
- Immunophenotyping is recommended for canine lymphomas and flow cytometry is suitable for this.
Conclusions:
- Flow cytometry is a valuable tool in small animal oncology, particularly for DNA analysis and immunophenotyping.
- Despite its utility, it has not yet become a routine technique in the field.
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