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Cyclopropyl and related analogs of the anti-HIV compound, isodideoxyadenosine
Vasu Nair1, Travis Mickle, Sanjib Bera
1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA. vnair@rx.uga.edu
Nucleosides, Nucleotides & Nucleic Acids
|June 21, 2003
Abstract:
Novel 3'-substituted isonucleoside analogs were designed on the basis of the similarities of their electrostatic potential with the active anti-HIV compound, (S,S)-isodideoxy-adenosine. The key synthetic step involved coupling between the dideoxygenated sugar derivatives, 10 and 14, and adenine under Mitsunobu conditions. Anti-HIV data are mentioned.