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Novel 12-membered ring macrolides with activity against erythromycin-resistant organisms
Peter A Nemoto1, Xiaolin Zhang, Stevan Djuric
1Infectious Disease Research, Abbott Laboratories, 200 Abbott Park Rd., Abbott Park, IL 60064-6217, USA.
The Journal of Antibiotics
|June 24, 2003
Abstract:
A series of novel 12-membered ring macrolides was designed based on available information on structure-activity relationships and macrolide-ribosome interactions. Compounds with the desosamine and the anchor group properly attached to the 12-membered lactone ring exhibited improved activity against erythromycin-resistant organisms.