Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Short introduction to gene imprinting].

J T Romer1

  • 1Institute of Cancer Reaearch, Chester Beatty Laboratories, London SW3 6JB.

Endokrynologia, Diabetologia I Choroby Przemiany Materii Wieku Rozwojowego : Organ Polskiego Towarzystwa Endokrynologow Dzieciecych
|June 24, 2003
PubMed
Summary

Genomic imprinting causes differential gene expression from parental genomes, leading to genetic diseases like Prader-Willi syndrome when imprinting is disrupted.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The upstream region of the mouse xist gene contains two ribosomal protein pseudogenes.

Mammalian genome : official journal of the International Mammalian Genome Society·2000
Same author

FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.

Genomics·2000
Same author

Xist has properties of the X-chromosome inactivation centre.

Nature·1997
Same author

KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats.

Cell adhesion and communication·1995
Same author

Synthesis and spectroscopy of membrane receptor proteins. The gamma subunit of the IgE receptor.

European journal of biochemistry·1992

Area of Science:

  • Genetics
  • Epigenetics
  • Developmental Biology

Context:

  • Genomic imprinting is a unique mammalian epigenetic phenomenon where parental genomes are not equivalent.
  • It involves differential marking and expression of specific gene alleles during gametogenesis.
  • This process results in monoallelic gene expression, rendering mammals functionally haploid for imprinted genes.

Purpose:

  • To review the complex genetic mechanisms underlying differential transcription of imprinted genes.
  • To highlight the role of genomic imprinting in mammalian development and adult life.
  • To explain how imprinting defects cause genetic disorders.

Summary:

  • Genomic imprinting leads to allele-specific gene expression, with one parental allele typically silenced.
  • Disruptions in imprinting, such as allele loss, mutation, or incorrect marking, can cause severe genetic diseases.
  • Examples of imprinting disorders include Beckwith-Wiedemann, Prader-Willi, and Angelman syndromes.

Impact:

  • Understanding genomic imprinting is crucial for diagnosing and potentially treating imprinting disorders.
  • This epigenetic mechanism influences embryonic development and physiological processes throughout life.
  • Imprinted genes represent a unique layer of genetic regulation with significant implications for health and disease.

Related Experiment Videos