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Updated: Sep 25, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

[Estimation of IGF-1 and IGFBP-3 concentrations in serum in children with diabetes type 1 and growth disorders]

E Barg, B Wikiera, J Bieniasz

    Endokrynologia, Diabetologia I Choroby Przemiany Materii Wieku Rozwojowego : Organ Polskiego Towarzystwa Endokrynologow Dzieciecych
    |June 24, 2003
    PubMed

    Insights

    In children with type 1 diabetes and growth issues, Insulin-like Growth Factor 1 (IGF-1) levels were higher with significant skeletal age delays. This finding was independent of growth hormone stimulation tests.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Disorders
    • Growth Hormone Axis

    Context:

    • The relationship between type 1 diabetes and growth disturbances remains debated.
    • Children with type 1 diabetes often experience growth issues, impacting their development.
    • Accurate assessment of growth factors is crucial for managing these complications.

    Purpose:

    • To investigate the levels of Insulin-like Growth Factor 1 (IGF-1) and IGF Binding Protein 3 (IGFBP-3) in children with type 1 diabetes and growth disturbances.
    • To explore correlations between IGF-1, IGFBP-3, Body Mass Index (BMI), and skeletal age in this cohort.
    • To determine the influence of skeletal age delay and growth hormone (GH) stimulation tests on IGF-1 concentrations.

    Summary:

    • This study analyzed 22 children (11.96+/-3.38 years) with type 1 diabetes and growth disturbances (GV SDS < -0.93).
    • Measurements included IGF-1, IGFBP-3, GH stimulation tests, TSH, fT4, and HbA1.
    • Positive correlations were found between IGF-1 and IGFBP-3, IGF-1 and BMI, and BMI and IGFBP-3.

    Impact:

    • IGF-1 concentrations were significantly higher in children with skeletal age delays exceeding one year compared to those with delays under one year.
    • This difference in IGF-1 was independent of the results from GH stimulation tests.
    • Findings suggest a complex interplay between type 1 diabetes, skeletal maturation, and the IGF-1 axis, potentially aiding in growth disturbance management.

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