[Transient cardiac enlargement: an unusual adverse event associated with growth hormone therapy]

Area of Science:

• Pediatric Endocrinology
• Pharmacovigilance
• Cardiology

Context:

• Growth hormone (GH) therapy is a common treatment for children with growth disorders.
• Monitoring for adverse events during GH therapy is crucial for patient safety.

Purpose:

• To report a case of transient edema and cardiac enlargement in a child receiving growth hormone therapy.
• To highlight the reversibility of these side effects with dose adjustment.

Summary:

• A 7-year-old boy experienced transient edema and cardiac enlargement within the first month of growth hormone (GH) therapy at a dose of 0.7 U/kg/week.
• These adverse events resolved rapidly upon reduction of the GH dosage.
• No further adverse events were noted after dose modification.

Impact:

• This case underscores the importance of vigilant monitoring for potential cardiovascular side effects during pediatric growth hormone treatment.
• It demonstrates that careful dose management can mitigate transient adverse events, ensuring treatment continuity and safety.