Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2.

Daejong Jeon1, Yu-Mi Yang, Myung-Jin Jeong

  • 1National Creative Research Initiative Center for Calcium & Learning, Korea Institute of Science and Technology, 136-791, Seoul, South Korea.

Neuron
|June 24, 2003
PubMed
Summary

Mice lacking the Na(+)/Ca(2+) exchanger 2 (NCX2) showed impaired calcium regulation in neurons. This led to altered synaptic plasticity and improved hippocampus-dependent learning and memory in mutant mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Responses of Carbon Nanotube/Polydimethylsiloxane Composite-Based Soft Resistive and Capacitive Strain Sensors Under Fast, Dynamic Loads.

Soft robotics·2026
Same author

Lipid-Enriched Gintonin from Korean Red Ginseng Marc Alleviates Obesity via Oral and Central Administration in Diet-Induced Obese Mice.

Nutrients·2025
Same author

Elevated O-GlcNAcylation Enhances Metabolic Rate and Reduces the Excitability of Hypothalamic ARC Neurons in 10-month-old Male Mice.

Experimental neurobiology·2025
Same author

Mediodorsal thalamic nucleus mediates resistance to ethanol through Ca<sub>v</sub>3.1 T-type Ca<sup>2+</sup> regulation of neural activity.

eLife·2025
Same author

Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection.

Proceedings of the National Academy of Sciences of the United States of America·2025

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • The plasma membrane Na(+)/Ca(2+) exchanger (NCX) regulates intracellular Ca(2+) levels through Ca(2+) efflux (forward mode) or influx (reverse mode).
  • NCX2 is the predominant isoform in the brain, suggesting a critical role in neural function.

Purpose of the Study:

  • To elucidate the in vivo physiological function of NCX2 in the brain.
  • To investigate the impact of NCX2 deficiency on neuronal Ca(2+) handling, synaptic plasticity, and cognitive behavior.

Main Methods:

  • Generation of NCX2-deficient mice.
  • Electrophysiological recordings in hippocampal CA1 neurons to assess Ca(2+) clearance and synaptic plasticity (LTP/LTD).
  • Behavioral testing of hippocampus-dependent learning and memory tasks.

Related Experiment Videos

Main Results:

  • Mutant hippocampal neurons displayed delayed clearance of elevated intracellular Ca(2+) after depolarization.
  • The frequency thresholds for long-term potentiation (LTP) and long-term depression (LTD) were lowered in NCX2-deficient mice, favoring LTP.
  • NCX2-deficient mice demonstrated enhanced performance in hippocampus-dependent learning and memory tasks.

Conclusions:

  • NCX2 acts as a temporal regulator of Ca(2+) homeostasis in the brain.
  • NCX2 is essential for controlling synaptic plasticity.
  • NCX2 plays a critical role in cognitive functions, including learning and memory.