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Related Experiment Videos

Fructose intolerance: an under-recognized problem.

Young K Choi1, Fredrick C Johlin, Robert W Summers

  • 1Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

The American Journal of Gastroenterology
|June 24, 2003
PubMed
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Fructose intolerance is common in patients with unexplained abdominal issues, with breath tests confirming symptoms in most. Higher fructose concentrations in breath tests increase positive results, aiding diagnosis.

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Clinical Nutrition

Background:

  • The role of fructose intolerance in unexplained gastrointestinal (GI) symptoms is not well understood.
  • Fructose intolerance is a condition where the body has difficulty absorbing fructose, leading to digestive discomfort.

Purpose of the Study:

  • To determine the prevalence of fructose intolerance in patients presenting with unexplained abdominal symptoms.
  • To investigate the impact of varying fructose concentrations on the accuracy and yield of the fructose breath test.

Main Methods:

  • 183 patients with unexplained GI symptoms underwent fructose breath tests (50g fructose, 33% solution), with hydrogen and methane levels measured.
  • A subset of patients received fructose breath tests with different concentrations (10%, 20%, 33%) to assess dose-dependency.

Related Experiment Videos

  • Retrospective analysis of questionnaire data and breath test results.

    • Main Results:

    • 73% of patients tested positive for fructose intolerance.
    • Common symptoms included flatus (83%), pain (80%), bloating (78%), and altered bowel habits (65%).
    • Positive test results increased significantly with higher fructose concentrations (39% at 10%, 70% at 20%, 80% at 33%).

    Conclusions:

    • Fructose intolerance is a likely cause of unexplained GI symptoms in a significant patient population.
    • The concentration of fructose used in breath testing influences the yield of positive results.
    • Diagnosing and managing fructose intolerance can provide relief for affected individuals.