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Improved reverse thermo-responsive polymeric systems.

Daniel Cohn1, Alejandro Sosnik, Avraham Levy

  • 1School of Applied Science and Technology, Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel. danielc@vms.huji.ac.il

Biomaterials
|June 24, 2003
PubMed
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New reverse thermo-responsive (RTG) polymers, synthesized from poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) segments, exhibit significantly enhanced rheological properties and improved drug delivery capabilities compared to existing systems.

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Reverse thermo-responsive (RTG) polymers exhibit sol-gel transitions upon heating.
  • Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, like Pluronic F127, are known for their RTG behavior.
  • Developing novel polymeric systems with enhanced properties is crucial for advanced applications.

Purpose of the Study:

  • To synthesize novel RTG polymeric systems with superior rheological properties.
  • To investigate the microstructure and drug delivery potential of these new polymers.
  • To compare the performance of novel polymers with existing Pluronic F127 systems.

Main Methods:

  • Synthesis of RTG polymers via bulk polymerization of Pluronic F127 with hexamethylene diisocyanate (HDI).

Related Experiment Videos

  • Synthesis of RTG polymers via covalent binding of poly(ethylene glycol) and poly(propylene glycol) chains using phosgene.
  • Characterization of rheological properties, microstructure using dynamic light scattering, and drug release kinetics.

    • Main Results:

    • Novel polymers achieved viscosities at least 15 times higher than Pluronic F127 at 37°C.
    • Microstructures formed by novel polymers were significantly larger (20-400nm) compared to Pluronic F127 micelles (15-20nm).
    • A 30% P[F127](4) gel delivered an anti-restenosis drug over 40 days, while a Pluronic F127 gel delivered it over 7 days.

    Conclusions:

    • Novel RTG polymeric systems demonstrate significantly improved rheological performance.
    • These novel polymers form larger nanostructures, indicating potential for enhanced encapsulation and controlled release.
    • The developed materials show promise as advanced drug delivery systems with prolonged therapeutic agent release.