Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unopposed orexic pathways in the developing fetus.

Michael G Ross1, Mostafa El-Haddad, Mina DeSai

  • 1University of California, Los Angeles, Harbor-UCLA Medical Center, 1000 West, Carson Street, Box 3, Torrance, CA 90509, USA. mikeross@ucla.edu

Physiology & Behavior
|June 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In a Rodent Model, Low-Dose Maternal Magnesium Sulfate Achieves Comparable Neuroinflammatory Attenuation to Higher Dose.

American journal of obstetrics and gynecology·2026
Same author

Maternal undernutrition in pregnancy and lactation programs impaired immune system development and function in male offspring.

Journal of developmental origins of health and disease·2026
Same author

Correction: Desai et al. TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. <i>Brain Sci.</i><b>2022</b>, <i>12</i>, 900.

Brain sciences·2025
Same author

Misinformation and Junk Science in Obstetrics Medical Malpractice.

O&G open·2025
Same author

Push count: a novel and quantitative approach to assessing second-stage labor progress in obese and non-obese patients.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2025
Same author

Imbalance of ω3 and ω6 Fatty Acids in Breast Milk of Overweight/Obese Women.

Nutrients·2025

Fetal appetite and satiety mechanisms develop in utero, potentially influencing lifelong eating habits. Maternal environment during gestation may impact these developing systems, possibly leading to later appetite dysfunction or obesity.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Gastroenterology

Background:

  • Fetal swallowing is crucial for gastrointestinal development and growth.
  • Ingestive behaviors must develop prenatally for neonatal feeding.
  • Mammalian fetuses possess mechanisms for food acquisition at birth.

Purpose of the Study:

  • To investigate the development of fetal appetite (orexic) and satiety mechanisms.
  • To determine if neurotransmitters involved in appetite regulation are functional in late gestation.
  • To explore the hypothesis that in utero imprinting of appetite mechanisms influences postnatal eating behaviors.

Main Methods:

  • Preliminary studies in ovine and human fetuses near term gestation.
  • Investigation of ingestive behavioral responses.

Related Experiment Videos

  • Assessment of orexic-mediated responses.

    • Main Results:

    • Preliminary data suggest the presence of orexic-mediated ingestive responses in late-gestation sheep and human fetuses.
    • Hypothesized development of both appetite and satiety mechanisms during the last third of gestation.
    • Neurotransmitters involved in appetite regulation are suggested to be functional.

    Conclusions:

    • Appetite and satiety systems likely develop in utero, with potential for early imprinting.
    • Maternal environmental factors during critical developmental stages may influence fetal appetite regulation.
    • Dysfunctional appetite and obesity may originate from prenatal influences on appetite set-points.