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Related Experiment Videos

C-reactive protein activates complement in infarcted human myocardium.

Remco Nijmeijer1, Wim K Lagrand, Yvonne T P Lubbers

  • 1Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

The American Journal of Pathology
|June 24, 2003
PubMed
Summary

C-reactive protein (CRP) activates complement in heart attack tissue, increasing inflammation. This CRP-mediated complement activation is significantly more pronounced in heart attacks over 12 hours old.

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Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathology

Background:

  • Circulating C-reactive protein (CRP) is a known cardiovascular risk marker.
  • Previous studies suggest CRP may enhance inflammation in ischemic myocardium by activating the complement system.
  • Co-localization of CRP and activated complement has been observed in human infarcted myocardium.

Purpose of the Study:

  • To determine if CRP activates complement within infarcted human myocardium.
  • To investigate the relationship between CRP-mediated complement activation and the duration of myocardial infarction.

Main Methods:

  • Analysis of myocardial tissue samples from 56 patients deceased from acute myocardial infarction.
  • Immunohistochemistry to assess CRP-mediated complement activation.

Related Experiment Videos

  • Measurement of complement, CRP, and CRP-complement complexes in heart tissue homogenates.

    • Main Results:

    • Infarctions older than 12 hours showed significantly greater deposition of complement and CRP compared to younger infarcts.
    • Tissues from older infarcts contained higher levels of CRP, activated complement, and CRP-complement complexes.
    • Levels of CRP-complement complexes correlated significantly with CRP and complement concentrations and deposition extent.

    Conclusions:

    • CRP appears to enhance local inflammatory reactions in human myocardial infarcts.
    • This enhancement is particularly evident in infarcts exceeding 12 hours in duration.
    • CRP-mediated complement activation plays a role in the inflammatory process of established myocardial infarction.