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Related Experiment Videos

Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling.

Itoshi Nikaido1, Chika Saito, Yosuke Mizuno

  • 1Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku Yokohama, Kanagawa 230-0045, Japan.

Genome Research
|June 24, 2003
PubMed
Summary

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Researchers identified candidate imprinted genes in the mouse genome using expression profiling and microarrays. This study provides a valuable resource for understanding genomic imprinting in inherited traits.

Area of Science:

  • Genomics
  • Developmental Biology
  • Epigenetics

Background:

  • Genomic imprinting is an epigenetic phenomenon where genes are expressed in a parent-of-origin-specific manner.
  • Understanding imprinted genes is crucial for deciphering mammalian development and inherited diseases.

Purpose of the Study:

  • To systematically identify candidate imprinted transcriptional units in the mouse genome.
  • To provide a comprehensive resource for studying the role of imprinting in mammalian inherited traits.

Main Methods:

  • Expression profiling of 27,663 FANTOM2 full-length mouse cDNA clones.
  • Large-scale cDNA microarrays to detect parent-of-origin differential expression in mouse embryos.
  • Mapping candidate imprinted transcripts to mouse and human genomes.

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Main Results:

  • Identified 2114 candidate imprinted transcripts from FANTOM2 data.
  • 39 candidates mapped to known imprinted regions, 56 were non-coding RNAs, and 159 were antisense transcripts.
  • Confirmed imprinted expression of two transcripts in the syntenic region of human Prader-Willi syndrome.

Conclusions:

  • The study presents a significant resource of candidate imprinted genes in the mouse.
  • Candidate imprinted transcripts show correlation with imprinting disease loci.
  • This data aids in understanding the role of imprinting in inherited traits and diseases.