Related Experiment Video

Updated: Jul 30, 2026

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
09:10

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

Published on: January 20, 2010

[Dystrophy caused by upper airway obstruction]

S Sandbu1, S H Slørdahl, E Oberger

  • 1Barneklinikken, Rikshospitalet, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 10, 1992
PubMed

Insights

Obstructive sleep apnea in infants can cause poor weight gain and developmental delays. Surgical intervention, such as adenotomy, significantly improved symptoms in affected infants, highlighting its importance in pediatric care.

Area of Science:

  • Pediatrics
  • Sleep Medicine
  • Developmental Biology

Background:

  • Infants presenting with poor weight gain, developmental delays, and recurrent respiratory infections require thorough evaluation.
  • Identifying underlying causes is crucial for effective intervention and improved infant outcomes.

Observation:

  • Three infants exhibited poor weight gain, delayed motor development, and recurrent respiratory infections.
  • Diagnostic evaluation revealed obstructive sleep apnea as a common underlying condition in these infants.

Findings:

  • Surgical intervention, specifically adenotomy or adenotonsillectomy, led to significant clinical improvement in all three infants.
  • Obstructive sleep apnea (OSA) is a treatable condition that can manifest with non-specific symptoms in infants.

Implications:

  • Obstructive sleep apnea should be considered in the differential diagnosis for infants with failure to thrive and developmental delays.
  • Timely diagnosis and surgical management of OSA can positively impact infant growth and development.
  • This case series underscores the importance of sleep-disordered breathing assessment in pediatric failure to thrive evaluations.

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