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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: Jun 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Nutritional considerations in osteoporosis.

Beth Kitchin1, Sarah Morgan

  • 1Department of Nutrition Sciences, University of Alabama at Birmingham, USA. bkitchin@uab.edu

Current Opinion in Rheumatology
|June 24, 2003
PubMed
Summary
This summary is machine-generated.

Proper nutrition is key for osteoporosis prevention and treatment. Recent findings highlight calcium, vitamin D, and other nutrients

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Area of Science:

  • Nutritional Science
  • Bone Health Research
  • Osteoporosis Management

Background:

  • Osteoporosis prevention and treatment rely heavily on nutrition therapy.
  • Calcium and vitamin D have been the primary nutritional focus for osteoporosis.
  • Emerging research explores additional nutrients and dietary patterns impacting bone health.

Purpose of the Study:

  • To review recent nutrition-related findings relevant to bone health.
  • To provide healthcare professionals with updated information for patient counseling.
  • To guide dietary modifications for improving bone mineral density and reducing fracture risk.

Main Methods:

  • Review of current scientific literature on nutrition and bone health.
  • Analysis of studies examining specific nutrients, foods, and dietary patterns.
  • Synthesis of recent research findings for clinical application.

Main Results:

  • Confirms the critical roles of calcium and vitamin D in bone health.
  • Identifies other nutrients and specific foods/beverages influencing bone density.
  • Emphasizes the importance of overall eating patterns for bone health.

Conclusions:

  • Updated nutritional strategies are essential for osteoporosis management.
  • Dietary recommendations should encompass a broader range of nutrients and food choices.
  • Healthcare professionals can leverage recent findings to enhance patient care and reduce fracture risk.